One of the rarest blood types is Rh-null (lacking all Rh antigens), according to the Cleveland Clinic. Certain rare blood types are unique to specific racial and ethnic groups for example, U-negative and Duffy-negative blood types are only found among African-Americans. However, not everyone’s blood falls into these eight categories. According to the American Red Cross, fewer than 1% of Americans have AB negative (AB-) blood, and fewer than 4% have AB positive (AB+) blood. Of the eight blood types, Group AB- is the least common blood type in the U.S.-and worldwide.
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